With this Dear Colleague Letter, the National Science Foundation’s (NSF) Directorate for Education and Human Resources (EHR), with leadership from the Division of Human Resource Development (HRD), seeks to increase the engagement of persons with disabilities in Science, Technology, Engineering, and Mathematics (STEM) fields and STEM education. Educating, preparing, and supporting persons with all types of disabilities, and of all ages, improves the skills of our nation’s current and future STEM workforce, as well as improves the prospects for all Americans to learn, work, and contribute to U.S. leadership in science and engineering discovery and innovation. A wide range of disability types are recognized in this Dear Colleague Letter including, but not limited to, deafness or hearing loss; blindness or visual impairment; physical, mental health, medical or other health-related disabilities; and neurodiverse conditions such as dyslexia, autism spectrum disorders, and learning disabilities.